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Article

FOSL1 Promotes Kras-induced Lung Cancer through Amphiregulin and Cell Survival Gene Regulation.

American journal of respiratory cell and molecular biology - 1 May 2018

Elangovan Indira M, Vaz Michelle, Tamatam Chandramohan R, Potteti Haranatha R, Reddy Narsa M, Reddy Sekhar P

Abstract excerpt

The FOSL1/AP-1 transcription factor regulates gene expression, thereby controlling various pathophysiological processes. It is a major effector of RAS-ERK1/2 signaling and is activated in human lung epithelia by tumorigenic stimuli. Recent evidence shows an inverse correlation between FOSL1 expression and the survival of patients with lung cancer and adenocarcinomas; however, its role in lung tumorigenesis...

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Topics

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Share to Adenocarcinoma of Lung
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Survival

Share to Extracellular Signal-Regulated MAP Kinases

Share to Gene Expression Regulation, Neoplastic

Share to Mice, Transgenic

Share to Proto-Oncogene Proteins c-fos

Share to Proto-Oncogene Proteins p21(ras)

Source

Open in PubMed Open full text

Identifiers

PMID: 29112457
DOI: 10.1165/rcmb.2017-0164OC
PMCID: PMC5946328

Genes

FOSL1
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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