Article
Activation of an inducible c-FosER fusion protein causes loss of epithelial polarity and triggers epithelial-fibroblastoid cell conversion.
Cell - 24 Dec 1992
Reichmann E, Schwarz H, Deiner E M, Leitner I, Eilers M, Berger J, Busslinger M, Beug H
Abstract excerpt
As a novel approach to studying the modulation of the polarized epithelial phenotype, we have expressed c-Fos and c-Myc estrogen receptor fusion proteins (c-FosER and c-MycER) in mammary epithelial cells. The hybrid proteins could be activated by estrogen for defined time periods and after the ce...
Topics
- Animals
- Cell Differentiation
- Cell Division
- Cell Line
- Cell Polarity
- Epithelial Cells
- Estrogens
- Fibroblasts
- Mammary Glands, Animal
- Mice
- Phenotype
- Proto-Oncogene Proteins c-fos
- Receptors, Estrogen
- Recombinant Fusion Proteins