Article

Group Heteroscedasticity - A Silent Saboteur of Power and False Discovery in RNA-Seq Differential Expression

2024-04-02

Abstract excerpt

Despite the availability of several high-profile, state-of-the-art methods, analyzing bulk RNA-Seq data continues to face significant challenges. Evidence from recent studies has highlighted that popular differential expression (DE) tools, such as edgeR and DESeq2, are susceptible to an alarmingly high false discovery rate (FDR). These studies suggest that the FDR inflation observed in these models could be attrib...

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Literature Corpus work: cd18cdfe-c8ba-56a4-9426-430232d702ef
DOI: 10.1101/2024.04.01.587633

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