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Article

Unequal group variances in microarray data analyses.

Bioinformatics (Oxford, England) - 1 May 2008

Demissie Meaza, Mascialino Barbara, Calza Stefano, Pawitan Yudi

Abstract excerpt

MOTIVATION: In searching for differentially expressed (DE) genes in microarray data, we often observe a fraction of the genes to have unequal variability between groups. This is not an issue in large samples, where a valid test exists that uses individual variances separately. The problem arises in the small-sample setting, where the approximately valid Welch test lacks sensitivity, while the more sensitive...

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PMID: 18344518
DOI: 10.1093/bioinformatics/btn100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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