Article

Stability and Performance of Linear Combination Tests of Gene Set Enrichment for Multiple Covariance Estimators in Unbalanced Studies

2025-01-26

Abstract excerpt

Gene set analysis (GSA) is essential for understanding coordinated gene expression changes within biological pathways, especially in high-dimensional data generated by platforms such as RNA-seq and microarrays. This study focuses on the linear combination test (LCT), a GSA method that combines multiple genelevel statistics into a powerful test statistic to assess the association between a gene set and outcomes of...

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Literature Corpus work: a74b7db8-1309-55f7-ab78-365b11df5df4
DOI: 10.1101/2025.01.23.634558

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