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Article

A drosophila model for EGFR-Ras and PI3K-dependent human glioma.

PLoS genetics - 1 Feb 2009

Read Renee D, Cavenee Webster K, Furnari Frank B, Thomas John B

Abstract excerpt

Gliomas, the most common malignant tumors of the nervous system, frequently harbor mutations that activate the epidermal growth factor receptor (EGFR) and phosphatidylinositol-3 kinase (PI3K) signaling pathways. To investigate the genetic basis of this disease, we developed a glioma model in Drosophila. We found that constitutive coactivation of EGFR-Ras and PI3K pathways in Drosophila glia and glial precursors...

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Identifiers

PMID: 19214224
DOI: 10.1371/journal.pgen.1000374
PMCID: PMC2636203

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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