Article
RanGTP mediates nuclear pore complex assembly.
Nature - 7 Aug 2003
Walther Tobias C, Askjaer Peter, Gentzel Marc, Habermann Anja, Griffiths Gareth, Wilm Matthias, Mattaj Iain W, Hetzer Martin
Abstract excerpt
In metazoa, the nuclear envelope breaks down and reforms during each cell cycle. Nuclear pore complexes (NPCs), which serve as channels for transport between the nucleus and cytoplasm, assemble into the reforming nuclear envelope in a sequential process involving association of a subset of NPC proteins, nucleoporins, with chromatin followed by the formation of a closed nuclear envelope fenestrated by NPCs. How...
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