Article
Expression of the human ferritin light chain in a frataxin mutant yeast affects ageing and cell death.
Experimental gerontology - 1 May 2004
Desmyter Liesbeth, Dewaele Sylviane, Reekmans Rieka, Nystrom Thomas, Contreras Roland, Chen Cuiying
Abstract excerpt
Ferritin is one of the major eukaryotic proteins involved in regulating iron metabolism and maintaining iron homeostasis. However, Saccaromyces cerevisiae is an exception, possessing no ferritin and using other means to store excess iron. The only potential iron storage protein identified in yeast so far is the homologue of human frataxin (YFH1p). In this study, we found that dysfunction of yeast frataxin...
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