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Major targets of iron-induced protein oxidative damage in frataxin-deficient yeasts are magnesium-binding proteins.

Free radical biology & medicine - 1 May 2008

Irazusta Verónica, Moreno-Cermeño Armando, Cabiscol Elisa, Ros Joaquim, Tamarit Jordi

Abstract excerpt

Iron accumulation has been associated with several pathological conditions such as Friedreich ataxia. This human disorder is caused by decreased expression of frataxin. Iron-overload triggers oxidative stress, but the main targets of such stress are not known. In yeast cells lacking the frataxin ortholog YFH1, we have identified a set of 14 carbonylated proteins, which include mitochondrial ATP synthase,...

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PMID: 18280258
DOI: 10.1016/j.freeradbiomed.2008.01.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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