The mitochondrial protein frataxin prevents nuclear damage.

doi:10.1093/hmg/11.11.1351

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Article

The mitochondrial protein frataxin prevents nuclear damage.

Human molecular genetics - 15 May 2002

Karthikeyan Gopalakrishnan, Lewis L Kevin, Resnick Michael A

Abstract excerpt

The mitochondrial protein frataxin helps maintain appropriate iron levels in the mitochondria of yeast and humans. A deficiency of this protein in humans causes Friedreich's ataxia, while its complete absence in yeast (Delta yfh1 mutant) results in loss of mitochondrial DNA, apparently due to radicals generated by excess iron. We found that the absence of frataxin in yeast also leads to nuclear damage, as...

Topics

Acetylcysteine
Adaptor Proteins, Signal Transducing
Carrier Proteins
Cell Nucleus
DNA Damage
Humans
Hydrogen Peroxide
Iron
Iron-Binding Proteins
Mitochondrial Proteins
Mutation
Nerve Tissue Proteins
Recombination, Genetic
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Sister Chromatid Exchange
Frataxin

Source

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Identifiers

PMID: 12019217
DOI: 10.1093/hmg/11.11.1351

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