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Article

Zinc suppresses the iron-accumulation phenotype of Saccharomyces cerevisiae lacking the yeast frataxin homologue (Yfh1).

The Biochemical journal - 15 Oct 2003

Santos Renata, Dancis Andrew, Eide David, Camadro Jean-Michel, Lesuisse Emmanuel

Abstract excerpt

Analysis of Saccharomyces cerevisiae cell transcriptome revealed that iron deprivation/supplementation affects genes other than those of the iron regulon (controlled by Aft proteins). Several genes regulated by zinc (induced by zinc deprivation) were induced by iron. Cells lacking the yeast frataxin homologue Yfh1 accumulate large amounts of iron in their mitochondria. We have shown that the zinc metabolism of...

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Identifiers

PMID: 12868958
DOI: 10.1042/BJ20030835
PMCID: PMC1223691

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Source receipt: pubmed, retrieved 7 Sept 2026.

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