Article
Binding of the Drosophila sex-lethal gene product to the alternative splice site of transformer primary transcript.
Nature - 29 Mar 1990
Inoue K, Hoshijima K, Sakamoto H, Shimura Y
Abstract excerpt
Somatic sexual differentiation in Drosophila melanogaster is accomplished by a hierarchy of genes of which one, Sex-lethal (Sxl), is required for the functional female-specific splicing of the transcripts of the immediately downstream regulatory gene, transformer (tra). The first exon of the tra primary transcript is spliced to one of two acceptor sites. Splicing to the upstream site yields a messenger RNA which...
Topics
- Animals
- Base Sequence
- Binding Sites
- DNA
- Drosophila melanogaster
- Escherichia coli
- Exons
- Female
- Gene Expression
- Genes, Lethal
- Genes, Regulator
- Molecular Sequence Data