Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Switch in 3' splice site recognition between exon definition and splicing catalysis is important for sex-lethal autoregulation.

Molecular and cellular biology - 1 Mar 2001

Penalva L O, Lallena M J, Valcárcel J

Abstract excerpt

Maintenance of female sexual identity in Drosophila melanogaster involves an autoregulatory loop in which the protein Sex-lethal (SXL) promotes skipping of exon 3 from its own pre-mRNA. We have used transient transfection of Drosophila Schneider cells to analyze the role of exon 3 splice sites in regulation. Our results indicate that exon 3 repression requires competition between the 5' splice sites of exons 2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenine Nucleotides
Share to Alternative Splicing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Catalysis

Share to Drosophila

Share to Drosophila Proteins

Share to Insect Hormones

Share to RNA-Binding Proteins

Share to RNA Splice Sites

Source

Open in PubMed Open full text

Identifiers

PMID: 11238934
DOI: 10.1128/MCB.21.6.1986-1996.2001
PMCID: PMC86793

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Switch in 3' splice site recognition between exon definition and splicing catalysis is important for sex-lethal autoregulation.PMID 11238934Read ↗

Splicing regulation at the second catalytic step by Sex-lethal involves 3' splice site recognition by SPF45.Semantic proximity Read ↗

Positive autoregulation of sex-lethal by alternative splicing maintains the female determined state in Drosophila.Semantic proximity Read ↗

Control of Drosophila Sex-lethal pre-mRNA splicing by its own female-specific product.Semantic proximity Read ↗

Binding of the Drosophila sex-lethal gene product to the alternative splice site of transformer primary transcript.Semantic proximity Read ↗

3' splice site recognition in nematode trans-splicing involves enhancer-dependent recruitment of U2 snRNP.Semantic proximity Read ↗

An N-terminal truncation uncouples the sex-transforming and dosage compensation functions of sex-lethal.Semantic proximity Read ↗

Induction of female Sex-lethal RNA splicing in male germ cells: implications for Drosophila germline sex determination.Semantic proximity Read ↗

Stop codons affect 5' splice site selection by surveillance of splicing.Semantic proximity Read ↗

The mechanism of somatic inhibition of Drosophila P-element pre-mRNA splicing: multiprotein complexes at an exon pseudo-5' splice site control U1 snRNP binding.Semantic proximity Read ↗

Differential effects of Sex-lethal mutations on dosage compensation early in Drosophila development.Semantic proximity Read ↗

Exon identity established through differential antagonism between exonic splicing silencer-bound hnRNP A1 and enhancer-bound SR proteins.Semantic proximity Read ↗

Functional conservation of the sex-lethal sex determining promoter, Sxl-Pe, in Drosophila virilis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.