Article
Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3.
Cell metabolism - 6 Oct 2020
Hall Jessica A, Ramachandran Deepti, Roh Hyun C, DiSpirito Joanna R, Belchior Thiago, Zushin Peter-James H, Palmer Colin, Hong Shangyu, Mina Amir I, Liu Bingyang, Deng Zhaoming, Aryal Pratik, Jacobs Christopher, Tenen Danielle, Brown Chester W, Charles Julia F, Shulman Gerald I, Kahn Barbara B, Tsai Linus T Y, Rosen Evan D, Spiegelman Bruce M, Banks Alexander S
Abstract excerpt
The thiazolidinediones (TZDs) are ligands of PPARγ that improve insulin sensitivity, but their use is limited by significant side effects. Recently, we demonstrated a mechanism wherein TZDs improve insulin sensitivity distinct from receptor agonism and adipogenesis: reversal of obesity-linked phosphorylation of PPARγ at serine 273. However, the role of this modification hasn't been tested genetically. Here we...
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