Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PPARgamma: a critical determinant of body fat distribution in humans and mice.

Trends in cardiovascular medicine - 1 Apr 2005

Tsai Yau-Sheng, Maeda Nobuyo

Abstract excerpt

Evidence emerging from studies of humans and mice has indicated peroxisome proliferator-activated receptor gamma (PPARgamma) to be not only a key factor for adipogenesis but also a critical determinant of body fat distribution. Whereas genetically reduced PPARgamma activity in adipose tissue leads to reduction of total fat mass in humans and in mice, mutations in the ligand-binding domain of PPARgamma cause...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Fat Distribution
Share to Ligands
Share to Metabolic Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Peroxisome Proliferator-Activated Receptors

Share to PPAR gamma

Share to Protein Structure, Tertiary

Source

Identifiers

PMID: 16039966
DOI: 10.1016/j.tcm.2005.04.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PPARgamma: a critical determinant of body fat distribution in humans and mice.PMID 16039966Read ↗

Mouse models of PPAR-γ deficiency: dissecting PPAR-γ's role in metabolic homoeostasisSemantic proximity Read ↗

PPARgamma in human and mouse physiology.Semantic proximity Read ↗

PPAR gamma as a metabolic regulator: insights from genomics and pharmacology.Semantic proximity Read ↗

Impact of genetic variation of PPARgamma in humans.Semantic proximity Read ↗

Peroxisome proliferator-activated receptor gamma (PPARgamma) and its ligands: a review.Semantic proximity Read ↗

PPARγ and metabolism: insights from the study of human genetic variantsSemantic proximity Read ↗

Peroxisome proliferator-activated receptor-gamma: too much of a good thing causes harm.Semantic proximity Read ↗

[Mutations of peroxisome proliferator-activated receptor gamma (PPARgamma): clinical implications].Semantic proximity Read ↗

PPARdelta regulates glucose metabolism and insulin sensitivity.Semantic proximity Read ↗

Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity.Semantic proximity Read ↗

Weight-loss-associated induction of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma correlate with reduced atherosclerosis and improved cardiovascular function in obese insulin-resistant mice.Semantic proximity Read ↗

Brown vs white adipocytes: The PPARγ coregulator storySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.