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Article

Peroxisome proliferator-activated receptor-gamma: too much of a good thing causes harm.

EMBO reports - 1 Feb 2004

Cock Terrie-Anne, Houten Sander M, Auwerx Johan

Abstract excerpt

The nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) helps to translate 'what you eat' into 'what you are' because it allows dietary fatty acids (PPARgamma ligands) to modulate gene transcription. Treatments for diabetes include PPARgamma activators, as they sensitize the body to insulin. Our understanding of PPARgamma function has recently been enhanced by a flurry of human and mouse...

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Identifiers

PMID: 14755307
DOI: 10.1038/sj.embor.7400082
PMCID: PMC1298993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Gene-Nutrient Interaction in Type 2 Diabetes: An Appraisal of the Role of the Peroxisome Proliferator-Activated Receptor Pathway.Semantic proximity Read ↗

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