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Article

Mouse models of PPAR-γ deficiency: dissecting PPAR-γ's role in metabolic homoeostasis

26 Oct 2005

Abstract excerpt

The identification of humans with mutations in PPAR-gamma (peroxisome-proliferator-activated receptor-gamma) has underlined its importance in the pathogenesis of the metabolic syndrome. Genetically modified mice provide powerful tools to dissect the mechanisms by which PPAR-gamma regulates metabolic processes. Ablation of PPAR-gamma in vivo is lethal and thus dissection of PPAR-gamma function using mouse models...

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PMID: 16246044
DOI: 10.1042/bst0331053

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