A genomic-systems biology map for cardiovascular function.

doi:10.1126/science.1062117

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Article

A genomic-systems biology map for cardiovascular function.

Science (New York, N.Y.) - 23 Nov 2001

Stoll M, Cowley A W, Tonellato P J, Greene A S, Kaldunski M L, Roman R J, Dumas P, Schork N J, Wang Z, Jacob H J

Abstract excerpt

With the draft sequence of the human genome available, there is a need to better define gene function in the context of systems biology. We studied 239 cardiovascular and renal phenotypes in 113 male rats derived from an F2 intercross and mapped 81 of these traits onto the genome. Aggregates of traits were identified on chromosomes 1, 2, 7, and 18. Systems biology was assessed by examining patterns of...

Topics

Animals
Blood Pressure
Cardiovascular Physiological Phenomena
Chromosome Mapping
Chromosomes
Crosses, Genetic
Female
Genomics
Humans
Kidney
Lod Score
Male
Nitric Oxide Synthase
Norepinephrine
Phenotype
Quantitative Trait, Heritable
Rats
Vasodilation

Source

Open in PubMed

Identifiers

PMID: 11721057
DOI: 10.1126/science.1062117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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