Article
Gender-specific genetic determinants of blood pressure and organ weight: pharmacogenetic approach.
Physiological research - 1 Jan 2003
Ueno T, Tremblay J, Kunes J, Zicha J, Dobesová Z, Pausova Z, Deng A Y, Sun Y, Jacob H J, Hamet P
Abstract excerpt
A total genome scan and pharmacogenetic study were designed to search for genetic determinants of blood pressure (BP) as well as heart and kidney weights. Genome scanning was carried out in 266 F(2) intercrosses from Prague hypertensive hypertriglyceridemic rats for phenotypes of organ weights, baseline BP, BP after blockade of the renin-angiotensin system (RAS) by losartan, of the sympathetic nervous system...
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