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Article

Direct binding of the ligand PSG17 to CD9 requires a CD9 site essential for sperm-egg fusion.

Molecular biology of the cell - 1 Dec 2003

Ellerman Diego A, Ha Cam, Primakoff Paul, Myles Diana G, Dveksler Gabriela S

Abstract excerpt

The function currently attributed to tetraspanins is to organize molecular complexes in the plasma membrane by using multiple cis-interactions. Additionally, the tetraspanin CD9 may be a receptor that binds the soluble ligand PSG17, a member of the immunoglobulin superfamily (IgSF)/CEA subfamily. However, previous data are also consistent with the PSG17 receptor being a CD9 cis-associated protein. In the current...

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Share to Immunoglobulins
Share to Antigens, CD
Share to Fluorescent Antibody Technique

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred ICR

Share to Oocytes

Share to Sperm Motility

Share to Sperm-Ovum Interactions

Share to Spermatozoa

Source

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Identifiers

PMID: 14528020
DOI: 10.1091/mbc.e03-04-0244
PMCID: PMC284811

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Direct binding of the ligand PSG17 to CD9 requires a CD9 site essential for sperm-egg fusion.PMID 14528020Read ↗

Residues SFQ (173-175) in the large extracellular loop of CD9 are required for gamete fusionSemantic proximity Read ↗

Sperm-Egg InteractionSemantic proximity Read ↗

CD9 tetraspanin generates fusion competent sites on the egg membrane for mammalian fertilizationSemantic proximity Read ↗

CD9 controls the formation of clusters that contain tetraspanins and the integrin α6β1, which are involved in human and mouse gamete fusionSemantic proximity Read ↗

Sperm-Egg Fusion: A Molecular Enigma of Mammalian ReproductionSemantic proximity Read ↗

Requirement of CD9 on the Egg Plasma Membrane for FertilizationSemantic proximity Read ↗

The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in miceSemantic proximity Read ↗

Infertility of CD9-deficient mouse eggs is reversed by mouse CD9, human CD9, or mouse CD81; polyadenylated mRNA injection developed for molecular analysis of sperm-egg fusion.Semantic proximity Read ↗

Human sperm TMEM95 binds eggs and facilitates membrane fusionSemantic proximity Read ↗

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Transfer of oocyte membrane fragments to fertilizing spermatozoaSemantic proximity Read ↗

CD81 and CD9 work independently as extracellular components upon fusion of sperm and oocyteSemantic proximity Read ↗

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