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Article

Requirement of CD9 on the Egg Plasma Membrane for Fertilization

14 Jan 2000

Abstract excerpt

CD9 is an integral membrane protein associated with integrins and other membrane proteins. Mice lacking CD9 were produced by homologous recombination. Both male and female CD9-/- mice were born healthy and grew normally. However, the litter size from CD9-/- females was less than 2% of that of the wild type. In vitro fertilization experiments indicated that the cause of this infertility was due to the failure of...

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PMID: 10634791
DOI: 10.1126/science.287.5451.321

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