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Article

CD81 and CD9 work independently as extracellular components upon fusion of sperm and oocyte

21 May 2012

Abstract excerpt

When a sperm and oocyte unite into one cell upon fertilization, membranous fusion between the sperm and oocyte occurs. In mice, Izumo1 and a tetraspanin molecule CD9 are required for sperm-oocyte fusion as one of the oocyte factors, and another tetraspanin molecule CD81 is also thought to involve in this process. Since these two tetraspanins often form a complex upon cell-cell interaction, it is probable that...

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Identifiers

PMID: 23213457
DOI: 10.1242/bio.20121420

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CD81 and CD9 work independently as extracellular components upon fusion of sperm and oocytePMID 23213457Read ↗

Possible involvement of CD81 in acrosome reaction of sperm in miceSemantic proximity Read ↗

Sperm-Egg Fusion: A Molecular Enigma of Mammalian ReproductionSemantic proximity Read ↗

Infertility of CD9-deficient mouse eggs is reversed by mouse CD9, human CD9, or mouse CD81; polyadenylated mRNA injection developed for molecular analysis of sperm-egg fusion.Semantic proximity Read ↗

Binding of sperm protein Izumo1 and its egg receptor Juno drives Cd9 accumulation in the intercellular contact area prior to fusion during mammalian fertilizationSemantic proximity Read ↗

Residues SFQ (173-175) in the large extracellular loop of CD9 are required for gamete fusionSemantic proximity Read ↗

Sperm–egg adhesion and fusion in mammalsSemantic proximity Read ↗

Transfer of oocyte membrane fragments to fertilizing spermatozoaSemantic proximity Read ↗

The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in miceSemantic proximity Read ↗

Sperm-Egg InteractionSemantic proximity Read ↗

Membrane transfer from oocyte to sperm occurs in two CD9-independent ways that do not supply the fertilising ability of <i>Cd9</i> -deleted oocytesSemantic proximity Read ↗

CD9 controls the formation of clusters that contain tetraspanins and the integrin α6β1, which are involved in human and mouse gamete fusionSemantic proximity Read ↗

Novel insights into the molecular mechanism of sperm–egg fusion via IZUMO1Semantic proximity Read ↗

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