Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in mice

26 Aug 2008

Abstract excerpt

Membrane fusion is an essential step in the encounter of two nuclei from sex cells-sperm and egg-in fertilization. However, aside from the involvement of two molecules, CD9 and Izumo, the mechanism of fusion remains unclear. Here, we show that sperm-egg fusion is mediated by vesicles containing CD9 that are released from the egg and interact with sperm. We demonstrate that the CD9(-/-) eggs, which have a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Reproductive Biology and Fertility
Share to Reproductive System and Pregnancy
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18728192
DOI: 10.1073/pnas.0710608105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in micePMID 18728192Read ↗

Sperm-Egg InteractionSemantic proximity Read ↗

Possible involvement of CD81 in acrosome reaction of sperm in miceSemantic proximity Read ↗

CD81 and CD9 work independently as extracellular components upon fusion of sperm and oocyteSemantic proximity Read ↗

New insights into the molecular basis of mammalian sperm-egg membrane interactionsSemantic proximity Read ↗

Sperm-Egg Fusion: A Molecular Enigma of Mammalian ReproductionSemantic proximity Read ↗

The gamete fusion process is defective in eggs of Cd9-deficient miceSemantic proximity Read ↗

Residues SFQ (173-175) in the large extracellular loop of CD9 are required for gamete fusionSemantic proximity Read ↗

Binding of sperm protein Izumo1 and its egg receptor Juno drives Cd9 accumulation in the intercellular contact area prior to fusion during mammalian fertilizationSemantic proximity Read ↗

Transfer of oocyte membrane fragments to fertilizing spermatozoaSemantic proximity Read ↗

Sperm–egg adhesion and fusion in mammalsSemantic proximity Read ↗

Infertility of CD9-deficient mouse eggs is reversed by mouse CD9, human CD9, or mouse CD81; polyadenylated mRNA injection developed for molecular analysis of sperm-egg fusion.Semantic proximity Read ↗

TMEM95 is a sperm membrane protein essential for mammalian fertilizationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.