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Article

Transfer of oocyte membrane fragments to fertilizing spermatozoa

15 Jun 2007

Abstract excerpt

Several families of molecules are implicated in the membrane fusion process between sperm and oocyte. Among these, CD9 tetraspanin, a membrane-organizing molecule, plays a crucial role, since the fertilizing ability of CD9-/- oocytes is dramatically impaired. CD9 controls alpha6-beta1 integrin relocation involved in the membrane reorganization that occurs on oocyte fertilization but is not expressed on sperm. We...

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PMID: 17575263
DOI: 10.1096/fj.06-8035hyp

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