Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Residues SFQ (173-175) in the large extracellular loop of CD9 are required for gamete fusion

15 Apr 2002

Abstract excerpt

Gamete fusion is the fundamental first step initiating development of a new organism. Female mice with a gene knockout for the tetraspanin CD9 (CD9 KO mice) produce mature eggs that cannot fuse with sperm. However, nothing is known about how egg surface CD9 functions in the membrane fusion process. We found that constructs including CD9's large extracellular loop significantly inhibited gamete fusion when...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Reproductive Biology and Fertility
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11934865
DOI: 10.1242/dev.129.8.1995

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Residues SFQ (173-175) in the large extracellular loop of CD9 are required for gamete fusionPMID 11934865Read ↗

Infertility of CD9-deficient mouse eggs is reversed by mouse CD9, human CD9, or mouse CD81; polyadenylated mRNA injection developed for molecular analysis of sperm-egg fusion.Semantic proximity Read ↗

CD81 and CD9 work independently as extracellular components upon fusion of sperm and oocyteSemantic proximity Read ↗

Direct binding of the ligand PSG17 to CD9 requires a CD9 site essential for sperm-egg fusion.Semantic proximity Read ↗

Sperm-Egg Fusion: A Molecular Enigma of Mammalian ReproductionSemantic proximity Read ↗

Transfer of oocyte membrane fragments to fertilizing spermatozoaSemantic proximity Read ↗

Sperm-Egg InteractionSemantic proximity Read ↗

Requirement of CD9 on the Egg Plasma Membrane for FertilizationSemantic proximity Read ↗

CD9 controls the formation of clusters that contain tetraspanins and the integrin α6β1, which are involved in human and mouse gamete fusionSemantic proximity Read ↗

The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in miceSemantic proximity Read ↗

CD9 tetraspanin generates fusion competent sites on the egg membrane for mammalian fertilizationSemantic proximity Read ↗

Possible involvement of CD81 in acrosome reaction of sperm in miceSemantic proximity Read ↗

The gamete fusion process is defective in eggs of Cd9-deficient miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.