Article

Human sperm TMEM95 binds eggs and facilitates membrane fusion

2022-06-10

Abstract excerpt

Tmem95 encodes a sperm acrosomal membrane protein, whose knockout has a male-specific sterility phenotype in mice. How TMEM95 plays a role in membrane fusion of sperm and eggs has remained elusive. Here, we utilize a sperm penetration assay as a model system to investigate the function of human TMEM95. We show that human TMEM95 binds to hamster egg membranes, providing evidence for a TMEM95 receptor on eggs. Using...

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Literature Corpus work: 52bb5323-1200-5ed9-bc3a-d31931602ee8
DOI: 10.1101/2022.06.10.495573

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