Article
Active localization of the retinoblastoma protein in chromatin and its response to S phase DNA damage.
Molecular cell - 1 Sept 2003
Avni Dror, Yang Hong, Martelli Fabio, Hofmann Francesco, ElShamy Wael M, Ganesan Shridar, Scully Ralph, Livingston David M
Abstract excerpt
The Rb protein suppresses development of an abnormal state of endoreduplication arising after S phase DNA damage. In diploid, S phase cells, the activity of protein phosphatase 2A (PP2A) licenses the stable association of un(der)phosphorylated Rb with chromatin. After damage, chromatin-associated pRb is attracted to certain chromosomal replication initiation sites in the order in which they normally fire. Like S...
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