Article
The retinoblastoma protein regulates pericentric heterochromatin.
Molecular and cellular biology - 1 May 2006
Isaac Christian E, Francis Sarah M, Martens Alison L, Julian Lisa M, Seifried Laurie A, Erdmann Natalie, Binné Ulrich K, Harrington Lea, Sicinski Piotr, Bérubé Nathalie G, Dyson Nicholas J, Dick Frederick A
Abstract excerpt
The retinoblastoma protein (pRb) has been proposed to regulate cell cycle progression in part through its ability to interact with enzymes that modify histone tails and create a repressed chromatin structure. We created a mutation in the murine Rb1 gene that disrupted pRb's ability to interact with these enzymes to determine if it affected cell cycle control. Here, we show that loss of this interaction slows...
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