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Article

The retinoblastoma protein regulates pericentric heterochromatin.

Molecular and cellular biology - 1 May 2006

Isaac Christian E, Francis Sarah M, Martens Alison L, Julian Lisa M, Seifried Laurie A, Erdmann Natalie, Binné Ulrich K, Harrington Lea, Sicinski Piotr, Bérubé Nathalie G, Dyson Nicholas J, Dick Frederick A

Abstract excerpt

The retinoblastoma protein (pRb) has been proposed to regulate cell cycle progression in part through its ability to interact with enzymes that modify histone tails and create a repressed chromatin structure. We created a mutation in the murine Rb1 gene that disrupted pRb's ability to interact wi...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16612004
DOI: 10.1128/MCB.26.9.3659-3671.2006
PMCID: PMC1447412

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16612004-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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