Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RB Loss Promotes Aberrant Ploidy by Deregulating Levels and Activity of DNA Replication Factors

8 Jun 2007

Abstract excerpt

The retinoblastoma tumor suppressor (RB) is functionally inactivated in many human cancers. Classically, RB functions to repress E2F-mediated transcription and inhibit cell cycle progression. Consequently, RB ablation leads to loss of cell cycle control and aberrant expression of E2F target genes. Emerging evidence indicates a role for RB in maintenance of genomic stability. Here, mouse adult fibroblasts were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17556357
DOI: 10.1074/jbc.m700542200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RB Loss Promotes Aberrant Ploidy by Deregulating Levels and Activity of DNA Replication FactorsPMID 17556357Read ↗

Liver-Specific pRB Loss Results in Ectopic Cell Cycle Entry and Aberrant PloidySemantic proximity Read ↗

Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control.Semantic proximity Read ↗

A retinoblastoma allele that is mutated at its common E2F interaction site inhibits cell proliferation in gene-targeted mice.Semantic proximity Read ↗

RB reversibly inhibits DNA replication via two temporally distinct mechanisms.Semantic proximity Read ↗

Inactivation of CtIP Leads to Early Embryonic Lethality Mediated by G1 Restraint and to Tumorigenesis by Haploid InsufficiencySemantic proximity Read ↗

Bloom's syndrome protein is required for correct relocalization of RAD50/MRE11/NBS1 complex after replication fork arrestSemantic proximity Read ↗

Retinoblastoma Tumor Suppressor Targets dNTP Metabolism to Regulate DNA ReplicationSemantic proximity Read ↗

Genetic instability as a consequence of inappropriate entry into and progression through S-phase.Semantic proximity Read ↗

Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive.Semantic proximity Read ↗

Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression.Semantic proximity Read ↗

The retinoblastoma protein regulates pericentric heterochromatin.Semantic proximity Read ↗

Activity of the Retinoblastoma Family Proteins, pRB, p107, and p130, during Cellular Proliferation and DifferentiationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.