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Article

Mitotic chromosome condensation mediated by the retinoblastoma protein is tumor-suppressive.

Genes & development - 1 Jul 2010

Coschi Courtney H, Martens Alison L, Ritchie Kieran, Francis Sarah M, Chakrabarti Subrata, Berube Nathalie G, Dick Frederick A

Abstract excerpt

Condensation and segregation of mitotic chromosomes is a critical process for cellular propagation, and, in mammals, mitotic errors can contribute to the pathogenesis of cancer. In this report, we demonstrate that the retinoblastoma protein (pRB), a well-known regulator of progression through the G1 phase of the cell cycle, plays a critical role in mitotic chromosome condensation that is independent of...

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Identifiers

PMID: 20551166
DOI: 10.1101/gad.1917610
PMCID: PMC2895195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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