pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F.

doi:10.1038/sj.onc.1202443

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Article

pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F.

Oncogene - 29 Oct 1998

Chew Y P, Ellis M, Wilkie S, Mittnacht S

Abstract excerpt

Progression of cells into S phase is controlled by the retinoblastoma protein (pRB) and relies on the functional inactivation of this tumour suppressor in late G1 via protein phosphorylation. We provide evidence here that, besides controlling entry of cells into S phase, pRB can operate to inhibi...

Topics

Blotting, Western
Carrier Proteins
Cell Cycle Proteins
Cell Division
Cell Line
Colony-Forming Units Assay
DNA
DNA-Binding Proteins
E2F Transcription Factors
G1 Phase
Humans
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phosphorylation

Retinoblastoma Protein

Retinoblastoma-Binding Protein 1

S Phase

Transcription Factor DP1

Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 9811449
DOI: 10.1038/sj.onc.1202443

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9811449-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F.PMID 9811449Read ↗

Cyclin E-induced S phase without activation of the pRb/E2F pathway.Semantic proximity Read ↗

Induction of S-Phase Entry by E2F Transcription Factors Depends on Their Nuclear LocalizationSemantic proximity Read ↗

Interchangeable Roles for E2F Transcriptional Repression by the Retinoblastoma Protein and p27KIP1-Cyclin-Dependent Kinase Regulation in Cell Cycle Control and Tumor Suppression.Semantic proximity Read ↗

Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression.Semantic proximity Read ↗

The retinoblastoma protein alters the phosphorylation state of polyomavirus large T antigen in murine cell extracts and inhibits polyomavirus origin DNA replication.Semantic proximity Read ↗

An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutant.Semantic proximity Read ↗

Cumulative effect of phosphorylation of pRB on regulation of E2F activity.Semantic proximity Read ↗

CDC25A Phosphatase Is a Target of E2F and Is Required for Efficient E2F-Induced S PhaseSemantic proximity Read ↗

The extreme COOH terminus of the retinoblastoma tumor suppressor protein pRb is required for phosphorylation on Thr-373 and activation of E2F.Semantic proximity Read ↗

Deregulated Expression of E2F Family Members Induces S-Phase Entry and Overcomes p16 <i> <sup>INK4A</sup> </i> -Mediated Growth SuppressionSemantic proximity Read ↗

Reverse mutational analysis reveals threonine-373 as a potentially sufficient phosphorylation site for inactivation of the retinoblastoma tumor suppressor protein (pRB).Semantic proximity Read ↗

Active RB elicits late G1/S inhibition.Semantic proximity Read ↗

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