Article
Active RB causes visible changes in nuclear organization.
The Journal of cell biology - 7 Mar 2022
Krishnan Badri, Yasuhara Takaaki, Rumde Purva, Stanzione Marcello, Lu Chenyue, Lee Hanjun, Lawrence Michael S, Zou Lee, Nieman Linda T, Sanidas Ioannis, Dyson Nicholas J
Abstract excerpt
RB restricts G1/S progression by inhibiting E2F. Here, we show that sustained expression of active RB, and prolonged G1 arrest, causes visible changes in chromosome architecture that are not directly associated with E2F inhibition. Using FISH probes against two euchromatin RB-associated regions, two heterochromatin domains that lack RB-bound loci, and two whole-chromosome probes, we found that constitutively...
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