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Article

In vitro and in vivo effects of tPA and PAI-1 on blood vessel tone.

Blood - 1 Feb 2004

Nassar Taher, Akkawi Sa'ed, Shina Ahuva, Haj-Yehia Abdullah, Bdeir Khalil, Tarshis Mark, Heyman Samuel N, Higazi Abd Al-Roof

Abstract excerpt

Tissue type plasminogen activator (tPA) is a key enzyme in the fibrinolytic cascade. In this paper we report that tPA contains 2 independent epitopes that exert opposite effects on blood vessel tone. Low concentrations of tPA (1 nM) inhibit the phenylephrine (PE)-induced contraction of isolated aorta rings. In contrast, higher concentrations (20 nM) stimulate the contractile effect of PE. The 2 putative...

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Source

Identifiers

PMID: 14512309
DOI: 10.1182/blood-2003-05-1685

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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