Article
Pharmacological and clinical impact of the unique molecular structure of a new plasminogen activator.
European heart journal - 1 Dec 1997
Smalling R W
Abstract excerpt
Thrombolytic therapy has been recognized as a significant improvement in the management of acute myocardial infarction. Thrombolytic agents however have been limited by short half-lives that necessitate complex administration protocols and by the potential for bleeding complications. The native t-PA molecule has since been modified in an attempt to achieve improved lytic characteristics with less risk of...
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