Article
Blood-brain barrier permeability and tPA-mediated neurotoxicity.
Neuropharmacology - 1 Jun 2010
Abu Fanne Rami, Nassar Taher, Yarovoi Sergei, Rayan Anwar, Lamensdorf Itschak, Karakoveski Michael, Vadim Polianski, Jammal Mahmud, Cines Douglas B, Higazi Abd Al-Roof
Abstract excerpt
Tissue type plasminogen activator (tPA) can induce neuronal apoptosis, disrupt the blood-brain barrier (BBB), and promote dilation of the cerebral vasculature. The timing, sequence and contributions of these and other deleterious effects of tPA and their contribution to post-ischemic brain damage after stroke, have not been fully elucidated. To dissociate the effects of tPA on BBB permeability, cerebral...
Topics
- Animals
- Blood-Brain Barrier
- Brain
- Capillary Permeability
- Fibrinolytic Agents
- Humans
- Infarction, Middle Cerebral Artery
- Mice
- Mutation
- Peptide Hydrolases
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Serpin E2