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Article

Blood-brain barrier permeability and tPA-mediated neurotoxicity.

Neuropharmacology - 1 Jun 2010

Abu Fanne Rami, Nassar Taher, Yarovoi Sergei, Rayan Anwar, Lamensdorf Itschak, Karakoveski Michael, Vadim Polianski, Jammal Mahmud, Cines Douglas B, Higazi Abd Al-Roof

Abstract excerpt

Tissue type plasminogen activator (tPA) can induce neuronal apoptosis, disrupt the blood-brain barrier (BBB), and promote dilation of the cerebral vasculature. The timing, sequence and contributions of these and other deleterious effects of tPA and their contribution to post-ischemic brain damage after stroke, have not been fully elucidated. To dissociate the effects of tPA on BBB permeability, cerebral...

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Identifiers

PMID: 20060006
DOI: 10.1016/j.neuropharm.2009.12.017
PMCID: PMC4423729

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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