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Article

Proteolytic regulation of epithelial sodium channels by urokinase plasminogen activator: cutting edge and cleavage sites.

The Journal of biological chemistry - 27 Feb 2015

Ji Hong-Long, Zhao Runzhen, Komissarov Andrey A, Chang Yongchang, Liu Yongfeng, Matthay Michael A

Abstract excerpt

Plasminogen activator inhibitor 1 (PAI-1) level is extremely elevated in the edematous fluid of acutely injured lungs and pleurae. Elevated PAI-1 specifically inactivates pulmonary urokinase-type (uPA) and tissue-type plasminogen activators (tPA). We hypothesized that plasminogen activation and fibrinolysis may alter epithelial sodium channel (ENaC) activity, a key player in clearing edematous fluid. Two-chain...

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Identifiers

PMID: 25555911
DOI: 10.1074/jbc.M114.623496
PMCID: PMC4342445

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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