Article
The pro- or antiangiogenic effect of plasminogen activator inhibitor 1 is dose dependent.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Feb 2002
Devy Laetitia, Blacher Silvia, Grignet-Debrus Christine, Bajou Khalid, Masson Veronique, Gerard Robert D, Gils Ann, Carmeliet Geert, Carmeliet Peter, Declerck Paul J, Nöel Agnès, Foidart Jean-Michel
Abstract excerpt
Plasminogen activator inhibitor 1 (PAI-1) is believed to control proteolytic activity and cell migration during angiogenesis. We previously demonstrated in vivo that this inhibitor is necessary for optimal tumor invasion and vascularization. We also showed that PAI-1 angiogenic activity is associated with its control of plasminogen activation but not with the regulation of cell-matrix interaction. To dissect the...
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