Article
Antidepressant effects of light therapy combined with sleep deprivation are influenced by a functional polymorphism within the promoter of the serotonin transporter gene.
Biological psychiatry - 1 Oct 2003
Benedetti Francesco, Colombo Cristina, Serretti Alessandro, Lorenzi Cristina, Pontiggia Adriana, Barbini Barbara, Smeraldi Enrico
Abstract excerpt
BACKGROUND: A functional polymorphism within the promoter of the serotonin transporter has been shown to influence the antidepressant response to serotonergic drug treatments and to total sleep deprivation (TSD). The short-term relapse that follows acute response to TSD has been successfully prevented by combining TSD with light therapy. The mechanism of action of this combined treatment is unknown. METHODS: We...
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