Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The serotonin transporter promoter polymorphism (5-HTTLPR) affects the relation between antidepressant serum concentrations and effectiveness in major depression.

Pharmacopsychiatry - 1 May 2012

Dreimüller N, Tadić A, Dragicevic A, Boland K, Bondy B, Lieb K, Laux G, Maier W, Müller M J, Rao M L, Rietschel M, Röschke J, Zill P, Hiemke C

Abstract excerpt

INTRODUCTION: Both the serotonin transporter promotor polymorphism (5-HTTLPR) and serum concentrations of SSRIs have been shown to affect response to SSRIs. Results, however, are inconsistent. The aim of this study was to investigate whether remission or response to SSRIs is influenced by an interaction of 5-HTTLPR and SSRI serum concentrations. METHODS: 49 patients with major depression and SSRI treatment were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antidepressive Agents
Share to Depressive Disorder, Major

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Linear Models

Share to Pharmacogenetics

Share to Promoter Regions, Genetic

Share to Selective Serotonin Reuptake Inhibitors

Share to Serotonin Plasma Membrane Transport Proteins

Share to Young Adult

Source

Identifiers

PMID: 22086748
DOI: 10.1055/s-0031-1291347

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The serotonin transporter promoter polymorphism (5-HTTLPR) affects the relation between antidepressant serum concentrations and effectiveness in major depression.PMID 22086748Read ↗

Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with antidepressant efficacy.Semantic proximity Read ↗

The influence of 5-HTTLPR genotype on the association between the plasma concentration and therapeutic effect of paroxetine in patients with major depressive disorder.Semantic proximity Read ↗

Serotonin transporter gene polymorphisms and treatment-resistant depression.Semantic proximity Read ↗

Is 5-HTTLPR linked to the response of selective serotonin reuptake inhibitors in MDD?Semantic proximity Read ↗

Moderation of antidepressant response by the serotonin transporter gene.Semantic proximity Read ↗

Serotonin transporter gene polymorphism and antidepressant response.Semantic proximity Read ↗

Role of serotonin transporter and receptor gene polymorphisms in treatment response to selective serotonin reuptake inhibitors in major depressive disorder.Semantic proximity Read ↗

Serotonin transporter gene promoter polymorphisms modify the association between paroxetine serotonin transporter occupancy and clinical response in major depressive disorder.Semantic proximity Read ↗

Association study of polymorphism in the serotonin transporter gene promoter, methylation profiles, and expression in patients with major depressive disorder.Semantic proximity Read ↗

5-HTTLPR-rs25531 and Antidepressant Treatment Outcomes in Korean Patients with Major Depression.Semantic proximity Read ↗

Antidepressant response and the serotonin transporter gene-linked polymorphic region.Semantic proximity Read ↗

Serotonin transporter promoter gene polymorphism and long-term outcome of antidepressant treatmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.