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Article

The effect of tryptophan on the cortisol response to social stress is modulated by the 5-HTTLPR genotype.

Psychoneuroendocrinology - 1 Feb 2013

Cerit Hilâl, Jans Linda A W, Van der Does Willem

Abstract excerpt

OBJECTIVE: The S'/S' (S/S, S/Lg and Lg/Lg) variant of the serotonin (5-HT) transporter gene linked polymorphic region (5-HTTLPR) is associated with less efficient neurotransmission and may be more reactive to 5-HT manipulations. We tested the effects of l-tryptophan supplements on the cortisol response induced by a social stressor in S'/S' and L'/L' (La/La) carriers. METHODS: In a double-blind parallel design, 25...

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PMID: 22717170
DOI: 10.1016/j.psyneuen.2012.05.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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