Article
Serotonin transporter gene promoter polymorphisms modify the association between paroxetine serotonin transporter occupancy and clinical response in major depressive disorder.
Pharmacogenetics and genomics - 1 Jan 2009
Ruhé Henricus G, Ooteman Wendy, Booij Jan, Michel Martin C, Moeton Martina, Baas Frank, Schene Aart H
Abstract excerpt
BACKGROUND: In major depressive disorder, selective serotonin reuptake inhibitors target the serotonin transporter (SERT). Their response rates (30-50%) are modified by SERT promotor polymorphisms (5-HTTLPR). OBJECTIVES: To quantify the relationship between SERT occupancy and response, and whether 5-HTTLPR is a modifier. METHODS: Drug-free depressed outpatients (n=49; both sexes; aged 25-55 years), received...
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