Article
Mutagenic properties of ribonucleotide analogues in reverse transcription with HIV and AMV reverse transcriptases.
Nucleic acids symposium series (2004) - 1 Jan 2005
Suzuki Tetsuya, Okada Toshiyuki, Otsuka Chie, Moriyama Kei, Loakes David, Negishi Kazuo
Abstract excerpt
Pyrimidine analogues, N4-hydroxycytosine (C(oh)), N4-methoxycytosine (C(mo)) and 6H, 8H-3,4-dihydropyrimido[4,5-c][1,2]oxazin-7-one (P) can form base pairs with both adenine and guanine. We examined the mutagenic properties of these ribonucleotide analogues in RNA in reverse transcription with HIV and AMV reverse transcriptases. Both reverse transcriptases incorporated dATP and dGTP opposite these analogues in...
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