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Article

High-resolution methylation analysis of the hMLH1 promoter in sporadic endometrial and colorectal carcinomas.

Cancer - 1 Oct 2003

Strazzullo Maria, Cossu Antonio, Baldinu Paola, Colombino Maria, Satta Maria P, Tanda Francesco, De Bonis Maria L, Cerase Andrea, D'Urso Michele, D'Esposito Maurizio, Palmieri Giuseppe

Abstract excerpt

BACKGROUND: Microsatellite instability (MSI) has been reported in endometrial carcinoma (EC) and in colorectal carcinoma (CRC), primarily as a result of defective DNA mismatch repair (MMR). The MMR gene hMLH1 commonly is inactivated in both EC and CRC. In the current study, epigenetic mechanisms involved in hMLH1 inactivation have been investigated to further elucidate the role of these mechanisms in the...

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PMID: 14508843
DOI: 10.1002/cncr.11651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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