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Article

Evaluation of microsatellite instability, hMLH1 expression and hMLH1 promoter hypermethylation in defining the MSI phenotype of colorectal cancer.

Cancer biology & therapy - 1 Jan 2004

Arnold Christian N, Goel Ajay, Compton Carolyn, Marcus Victoria, Niedzwiecki Donna, Dowell Jeannette M, Wasserman Linda, Inoue Toru, Mayer Robert J, Bertagnolli Monica M, Boland C Richard

Abstract excerpt

INTRODUCTION: About 15% of all colorectal cancers (CRCs) demonstrate high levels of microsatellite instability (MSI-H) and are currently best identified by molecular analysis of microsatellite markers. Most sporadic CRCs with MSI-H are known to be associated with the methylation of the hMLH1 promoter. Promoter methylation coincided with lack of hMLH1 expression. We aimed to investigate the association between MSI...

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PMID: 14726676
DOI: 10.4161/cbt.3.1.590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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