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Article

MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas.

Oncogene - 5 Nov 1998

Esteller M, Levine R, Baylin S B, Ellenson L H, Herman J G

Abstract excerpt

Microsatellite instability (MSI) has been detected in endometrial carcinomas occurring in women affected by hereditary nonpolyposis colorectal carcinoma (HNPCC) as well as in 20% of presumably sporadic endometrial tumors. While the MSI+ phenotype observed in endometrial tumors from HNPCC patients is attributed to germ line mutations in mismatch repair (MMR) genes, somatic mutations of known MMR genes are...

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Source

Identifiers

PMID: 9811473
DOI: 10.1038/sj.onc.1202178

Genes

MLH1
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas.PMID 9811473Read ↗

MLH1 Promoter Methylation and Gene Silencing is the Primary Cause of Microsatellite Instability in Sporadic Endometrial CancersSemantic proximity Read ↗

MSI in endometrial carcinoma: absence of MLH1 promoter methylation is associated with increased familial risk for cancers.Semantic proximity Read ↗

Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers.Semantic proximity Read ↗

Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers.Semantic proximity Read ↗

Frequent hypermethylation of MLH1 promoter in normal endometrium of patients with endometrial cancers.Semantic proximity Read ↗

Methylation of the hMLH1 promoter but no hMLH1 mutations in sporadic gastric carcinomas with high-level microsatellite instability.Semantic proximity Read ↗

Increased risk for hereditary nonpolyposis colorectal cancer-associated synchronous and metachronous malignancies in patients with microsatellite instability-positive endometrial carcinoma lacking MLH1 promoter methylation.Semantic proximity Read ↗

Differential involvement of the hypermethylator phenotype in hereditary and sporadic colorectal cancers with high-frequency microsatellite instability.Semantic proximity Read ↗

Microsatellite instability and hMLH1/hMSH2 expression in young endometrial carcinoma patients: associations with family history and histopathology.Semantic proximity Read ↗

High-resolution methylation analysis of the hMLH1 promoter in sporadic endometrial and colorectal carcinomas.Semantic proximity Read ↗

Microsatellite Instability in Endometrial Carcinoma by Immunohistochemistry, Association with Clinical and Histopathologic ParametersSemantic proximity Read ↗

The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability.Semantic proximity Read ↗

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