Article
MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas.
Oncogene - 5 Nov 1998
Esteller M, Levine R, Baylin S B, Ellenson L H, Herman J G
Abstract excerpt
Microsatellite instability (MSI) has been detected in endometrial carcinomas occurring in women affected by hereditary nonpolyposis colorectal carcinoma (HNPCC) as well as in 20% of presumably sporadic endometrial tumors. While the MSI+ phenotype observed in endometrial tumors from HNPCC patients...
Topics
- Adaptor Proteins, Signal Transducing
- Carrier Proteins
- DNA-Binding Proteins
- Endometrial Neoplasms
- Female
- Humans
- Methylation
- Microsatellite Repeats
- MutL Protein Homolog 1
- MutS Homolog 2 Protein
- Neoplasm Proteins
- Nuclear Proteins
- Phenotype
- Proto-Oncogene Proteins