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Article

The profile of hMLH1 methylation and microsatellite instability in colorectal and non-small cell lung cancer.

International journal of molecular medicine - 1 Jan 2005

Okuda Toshiyuki, Kawakami Kazuyuki, Ishiguro Kaname, Oda Makoto, Omura Kenji, Watanabe Go

Abstract excerpt

Microsatellite instability (MSI) is caused mainly by dysfunction of hMLH1, where aberrant hypermethylation (HM) of its promoter region is involved. Previously, we suggested that HM in the proximal region of the hMLH1 promoter plays a critical role in progression of gastric cancer with MSI and this specific region should be analyzed for diagnostic use of hMLH1 HM. We expanded the analyses of hMLH1 HM and MSI...

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PMID: 15583832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The profile of hMLH1 methylation and microsatellite instability in colorectal and non-small cell lung cancer.PMID 15583832Read ↗

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