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Article

Frequent hypermethylation of MLH1 promoter in normal endometrium of patients with endometrial cancers.

Oncogene - 17 Apr 2003

Kanaya Taro, Kyo Satoru, Maida Yoshiko, Yatabe Noriyuki, Tanaka Masaaki, Nakamura Mitsuhiro, Inoue Masaki

Abstract excerpt

Silencing of the MLH1 gene by promoter hypermethylation is the mechanism underlying the microsatellite instability (MSI) phenotype in endometrial cancers. However, the profile of CpG methylation in a wide range of MLH1 promoters in endometrial cancers and in the normal endometrium is largely unknown. The present study investigates the region 700 bp upstream of MLH1 covering 48 CpG sites using bisulfite...

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Share to Base Pair Mismatch
Share to Carcinoma, Endometrioid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

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Source

Identifiers

PMID: 12700670
DOI: 10.1038/sj.onc.1206365

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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