Article
hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability.
Cancer research - 1 Jan 1999
Leung S Y, Yuen S T, Chung L P, Chu K M, Chan A S, Ho J C
Abstract excerpt
Mutation of DNA mismatch repair genes has rarely been documented in sporadic gastric carcinoma with microsatellite instability (MSI). In sporadic colorectal carcinoma, hMLH1 promoter methylation associated with protein loss is found in the majority of high-frequency MSI cases. We investigated a s...
Topics
- Adaptor Proteins, Signal Transducing
- Carcinoma
- Carrier Proteins
- DNA Methylation
- DNA Repair
- DNA, Satellite
- Gene Expression Regulation, Neoplastic
- Humans
- MutL Protein Homolog 1
- Mutation
- Neoplasm Proteins
- Nuclear Proteins
- Promoter Regions, Genetic
- Stomach Neoplasms