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Article

MSI in endometrial carcinoma: absence of MLH1 promoter methylation is associated with increased familial risk for cancers.

International journal of cancer - 10 Jun 2002

Whelan Alison J, Babb Sheri, Mutch David G, Rader Janet, Herzog Thomas J, Todd Christina, Ivanovich Jennifer L, Goodfellow Paul J

Abstract excerpt

Loss of DNA mismatch repair occurs in a variety of malignancies and is associated with genome-wide instability of microsatellite repeats, a molecular phenotype referred to as microsatellite instability (MSI). MSI is a consistent feature of colorectal and endometrial tumors from patients with hereditary non-polyposis colorectal cancer (HNPCC). Sporadic colorectal and endometrial cancers that exhibit MSI frequently...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12115503
DOI: 10.1002/ijc.10429

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

MSI in endometrial carcinoma: absence of MLH1 promoter methylation is associated with increased familial risk for cancers.PMID 12115503Read ↗

MLH1 Promoter Methylation and Gene Silencing is the Primary Cause of Microsatellite Instability in Sporadic Endometrial CancersSemantic proximity Read ↗

Increased risk for hereditary nonpolyposis colorectal cancer-associated synchronous and metachronous malignancies in patients with microsatellite instability-positive endometrial carcinoma lacking MLH1 promoter methylation.Semantic proximity Read ↗

Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers.Semantic proximity Read ↗

Genetic and epigenetic modification of MLH1 accounts for a major share of microsatellite-unstable colorectal cancers.Semantic proximity Read ↗

MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas.Semantic proximity Read ↗

Differential involvement of the hypermethylator phenotype in hereditary and sporadic colorectal cancers with high-frequency microsatellite instability.Semantic proximity Read ↗

Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigeneticsSemantic proximity Read ↗

Microsatellite instability and hMLH1/hMSH2 expression in young endometrial carcinoma patients: associations with family history and histopathology.Semantic proximity Read ↗

Prediction of a mismatch repair gene defect by microsatellite instability and immunohistochemical analysis in endometrial tumours from HNPCC patients.Semantic proximity Read ↗

Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening.Semantic proximity Read ↗

Colorectal carcinogenesis: MSI-H versus MSI-L.Semantic proximity Read ↗

Genetic instability in human mismatch repair deficient cancers.Semantic proximity Read ↗

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