Molecular characterization of endometrial cancer: a correlative study assessing microsatellite instability, MLH1 hypermethylation, DNA mismatch repair protein expression, and PTEN, PIK3CA, KRAS, and BRAF mutation analysis.

doi:10.1097/PGP.0b013e318231fc51

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Article

Molecular characterization of endometrial cancer: a correlative study assessing microsatellite instability, MLH1 hypermethylation, DNA mismatch repair protein expression, and PTEN, PIK3CA, KRAS, and BRAF mutation analysis.

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists - 1 May 2012

Peterson Lisa M, Kipp Benjamin R, Halling Kevin C, Kerr Sarah E, Smith David I, Distad Tammy J, Clayton Amy C, Medeiros Fabiola

Abstract excerpt

Endometrial cancer is associated with numeric and structural chromosomal abnormalities, microsatellite instability (MSI), and alterations that activate oncogenes and inactivate tumor suppressor genes. The aim of this study was to characterize a set of endometrial cancers using multiple molecular genetic and immunohistochemical techniques. Ninety-six cases were examined for genomic alterations by MSI, MLH1...

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Identifiers

PMID: 22498935
DOI: 10.1097/PGP.0b013e318231fc51

Genes

MLH1
BRAF
KRAS
MSH6
PMS2
PTEN
MSH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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